Dong-Qing Wei Selected Research

Enzymes

1/2023	Exploring the natural products chemical space through a molecular search to discover potential inhibitors that target the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD).
1/2022	Screening of immune epitope in the proteome of the Dabie bandavirus, SFTS, to design a protein-specific and proteome-wide vaccine for immune response instigation using an immunoinformatics approaches.
8/2021	Virtual screening-driven drug discovery of SARS-CoV2 enzyme inhibitors targeting viral attachment, replication, post-translational modification and host immunity evasion infection mechanisms.
7/2021	Interrogation of Bacillus anthracis SrtA active site loop forming open/close lid conformations through extensive MD simulations for understanding binding selectivity of SrtA inhibitors.
3/2021	Potential Cancer- and Alzheimer's Disease-Targeting Phosphodiesterase Inhibitors from Uvaria alba: Insights from In Vitro and Consensus Virtual Screening.
2/2018	Prediction of Effective Drug Combinations by an Improved Naïve Bayesian Algorithm.
8/2003	Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS.

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Dong-Qing Wei Research Topics

Disease

23	Infections 02/2024 - 10/2009
21	Neoplasms (Cancer) 03/2024 - 01/2018
13	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 12/2005
11	COVID-19 04/2023 - 01/2021
10	Breast Neoplasms (Breast Cancer) 01/2024 - 01/2019
5	Uterine Cervical Neoplasms (Cancer of the Cervix) 03/2021 - 01/2018
4	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2023 - 01/2018
4	Human Influenza (Influenza) 10/2013 - 10/2009
4	Severe Acute Respiratory Syndrome 01/2006 - 08/2003
3	Virus Diseases (Viral Diseases) 05/2024 - 05/2013
3	Prostatic Neoplasms (Prostate Cancer) 01/2024 - 01/2022
3	Reinfection 12/2023 - 11/2021
3	Inflammation (Inflammations) 03/2021 - 12/2019
3	Lung Neoplasms (Lung Cancer) 01/2021 - 01/2019
3	Influenza in Birds (Avian Flu) 01/2021 - 05/2009
2	Liver Neoplasms (Liver Cancer) 03/2024 - 01/2020
2	Hypoxia (Hypoxemia) 01/2023 - 06/2021
2	Fever (Fevers) 01/2022 - 10/2021
2	Vomiting 01/2022 - 01/2022
2	Rupture 07/2021 - 10/2014
2	Hypersensitivity (Allergy) 06/2021 - 01/2020
2	Pain (Aches) 01/2020 - 05/2010
2	Chronic Disease (Chronic Diseases) 01/2020 - 01/2020
2	Parkinson Disease (Parkinson's Disease) 03/2019 - 01/2018
2	Neoplasm Metastasis (Metastasis) 01/2019 - 01/2019
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019 - 10/2018
2	Drug-Related Side Effects and Adverse Reactions 02/2018 - 01/2009
2	Shock 07/2014 - 11/2012
1	Esophageal Neoplasms (Esophageal Cancer) 10/2023
1	Cholangiocarcinoma 01/2023
1	Anemia 01/2023
1	Breakthrough Infections 01/2023
1	Sepsis (Septicemia) 01/2023
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2023
1	Tuberculosis (Tuberculoses) 01/2023
1	Lassa Fever (Fever, Lassa) 11/2022

Drug/Important Bio-Agent (IBA)

24	VaccinesIBA 02/2024 - 01/2018
18	Proteins (Proteins, Gene)FDA Link 12/2023 - 09/2012
9	Biomarkers (Surrogate Marker)IBA 10/2023 - 10/2018
8	Peptides (Polypeptides)IBA 04/2023 - 02/2017
7	EnzymesIBA 01/2023 - 08/2003
6	LigandsIBA 11/2021 - 09/2009
5	MicroRNAs (MicroRNA)IBA 01/2024 - 01/2020
5	Messenger RNA (mRNA)IBA 06/2021 - 10/2018
4	Amyloid (Amyloid Fibrils)IBA 05/2023 - 02/2017
4	Antiviral Agents (Antivirals)IBA 01/2023 - 01/2018
4	EpitopesIBA 01/2022 - 01/2018
3	ProteomeIBA 03/2021 - 01/2019
3	Amantadine (Aman)FDA LinkGeneric 10/2013 - 10/2009
3	Rimantadine FDA LinkGeneric 10/2013 - 10/2009
3	rupintrivirIBA 05/2009 - 08/2003
2	ErbB Receptors (EGF Receptor)IBA 09/2023 - 06/2019
2	Dopamine (Intropin)FDA LinkGeneric 03/2023 - 01/2018
2	Transcription Factors (Transcription Factor)IBA 01/2023 - 01/2021
2	Membrane Transport Proteins (Biological Pump)IBA 01/2023 - 01/2019
2	Amino Acids FDA Link 10/2022 - 01/2018
2	Androgen Receptors (Androgen Receptor)IBA 10/2022 - 01/2022
2	Antimicrobial PeptidesIBA 11/2021 - 01/2021
2	AcetylcholinesteraseIBA 09/2021 - 03/2021
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 09/2021 - 03/2021
2	Anti-Bacterial Agents (Antibiotics)IBA 03/2021 - 01/2018
2	Neuraminidase (Sialidase)IBA 01/2021 - 05/2009
2	Protein Subunit VaccinesIBA 01/2021 - 01/2018
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 10/2020
2	lemairaminIBA 01/2020 - 11/2017
2	Long Noncoding RNAIBA 01/2020 - 01/2020
2	octogen (HMX)IBA 07/2014 - 11/2012
2	Protons (Proton)IBA 10/2013 - 05/2013
2	alpha7 Nicotinic Acetylcholine ReceptorIBA 02/2013 - 05/2009
2	3-(2,4-dimethoxybenzylidene)anabaseineIBA 01/2008 - 09/2007
2	Peptide Hydrolases (Proteases)FDA Link 11/2004 - 08/2003
1	InterferonsIBA 05/2024
1	Neuregulin-1 (Neuregulin 1)IBA 09/2023
1	Growth Factor ReceptorsIBA 04/2023
1	IntegrinsIBA 04/2023
1	PaxillinIBA 04/2023
1	GoldIBA 03/2023
1	Furosemide (Lasix)FDA LinkGeneric 03/2023
1	PLX 4720IBA 03/2023
1	AZD 6244IBA 03/2023
1	mirdametinibIBA 03/2023
1	palbociclibIBA 03/2023
1	PanobinostatIBA 03/2023
1	tanespimycin (17AAG)IBA 03/2023
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2023
1	Scopolamine (Hyoscine)FDA Link 01/2023
1	Interleukin-6 (Interleukin 6)IBA 01/2023
1	Interleukin-10 (Interleukin 10)IBA 01/2023
1	ZincIBA 01/2023
1	Interleukin-17 (Interleukin 17)IBA 01/2023
1	Heparin (Liquaemin)FDA LinkGeneric 01/2023
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2023
1	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 01/2023
1	fibrin fragment D (D-dimer)IBA 01/2023
1	AngiotensinogenIBA 11/2022
1	ReninIBA 11/2022

Therapy/Procedure

19	Therapeutics 03/2023 - 01/2006
3	Immunotherapy 03/2024 - 01/2018
1	Drug Therapy (Chemotherapy) 01/2023
1	Immunomodulation 01/2023